This course is designed to give undergraduate students in the School of Pharmacy an overall understanding of the modern art of drug discovery. The lecture-style class will address the multidisciplinary nature, key technologies including AI-enabled drug design, case studies of successes and failures, and a unifying paradigm of drug discovery. The teaching will be conducted in plain English, with the aid of PowerPoint slides show, to make complex issues and technical jargons easily understandable. The students will be assigned some homework before some classes and fully credited after passing a final exam. The ultimate purpose of this class is to motivate students in pursuing a professional career of innovative drug discovery.