This course will introduce the undergraduate students on materials structures and properties that requires to serve the clinical purpose. The students will learn on how they interact with the different components of biological systems (e.g., tissue to biomolecule). The students will develop their understanding on why one material integrate, or other fails. The student will develop analytical insights on how physical and chemical properties of a materials play critical role while interfacing a biological surface/molecules. This UIP course will introduce them to the concept of biofunctions to familiarise with the native environment and how do they facilitate for bio-integration. At the end of this UIP course, the students will clearly understand the importance of cross-disciplinary approach on how physics, chemistry and biology are coming together when developing a new material for a medical application.