Optimal decision-making and innovation techniques are important to individuals and organizations to improve their performance and sustainable development. Decision-making and innovation are facing many opportunities in the age of digital intelligence with various new technologies emerging and adopted. However, decision-making is also challenging due to various influential factors and their tradeoffs. This course focuses on advanced and current decision-making and innovation techniques and topics in the age of digital intelligence, including artificial intelligence, blockchain, cloud computing, big data analysis, digital transformation techniques, uncertainty and risk management, simulation, sustainability, decision support systems, etc. to cultivate students to use various mathematical, statistics, information, and digital intelligence techniques to support decision making and innovation for individuals and organizations.