This course is designed to provide the fundamental knowledge and essential concepts in the emerging field of psychoneuroimmunology (PNI). PNI is an interdisciplinary science that studies the connection and influence between the central nervous system, the immune system, and behavior. Understanding the interplay between these systems leads to discoveries of novel mechanisms of physiology and pathology, developments of novel therapies for the treatments of inflammatory diseases, neurodegenerative and affective disorders. The course seeks to provide a basic understanding of the neuroscience, immunology, physiology and behavioral science underlying PNI interactions and to use PNI research as a platform to present students with modern strategies for understanding molecular mechanisms involved in the immunomodulation of neural functions and neuromodulation of immune activities.