四川大学国际课程周
SICHUAN UNIVERSITY UIP 2022
教师 Teacher
T Ali. K. Yetisen
       华西基础医学与法医学院
课程名称 Course Title
Biochemical Sensors

The ongoing COVID-19 pandemic has demonstrated that rapid medical testing was an indispensable need of healthcare systems worldwide to identify high-risk patients who need urgent treatment. Designing novel materials and biosensors for applications in medical technologies are key to saving lives and delivering efficient, reliable, and low-cost solutions for clinicians and patients. Medical technologies can be developed as benchtop handheld, and wearable biochemical sensors to collect biomarker information for diagnosing metabolic disorders, diseases, and infections.

课程大纲 Course Outline
"1. Biochemical sensors To demonstrate the concepts and applications in optical sensors (chromogenic, fluorescent, bioluminescent, biophotonic) and applications in benchtop, handheld and wearable diagnostic devices. 2. Colorimetric biosensors To demonstrate the concepts and applications in optical sensors (chromogenic, fluorescent, bioluminescent, biophotonic) and applications in benchtop, handheld and wearable diagnostic devices. 3. Fluorescent biosensors To demonstrate the concepts and applications in fluorescent sensors providing an overview of the challenges and limitations in benchtop, handheld, wearable, and implantable fluorescent diagnostic devices. 4. Plasmonic biosensors To demonstrate the concepts and applications in the plasmonic sensors providing an overview of the challenges and limitations in the plasmonic biosensors. 5. Paper-based biosensors To describe the principle and types of paper-based lateral-flow tests providing the applications and challenges of current technologies of paper-based biosensors. 6. Microfluidic biosensors To explore the concept of microelectromechanical systems (MEMS) and microfluidic devices and provide an outline of the state-of-the-art technologies in multiplexed detection of biomarkers. 7. Wearable and implantable biosensors To apply the concepts and applications of multiplexed assays to wearable and implantable biosensors in the detection of sweat and interstitial fluid biomarkers for real-time patient monitoring. 8. Readout devices and data acquisition To identify the basics of reading data from diagnostic assays using benchtop, handheld, smartphone-based analyzers and to explore biophysical and biochemical data collection in monitoring vital signs. 9. Design projects To develop a biochemical sensor for diagnostics that will solve a global unmet medical problem in infectious diseases and companion diagnostics."