The goal of this course is to help students: 1) understand basics of vascular biology (both the blood and lymphatic vascular systems) in health; I will cover vascular development and homeostasis, 2) use basic concept of vascular biology to explain disease pathogenesis; I will cover pulmonary hypertension, chronic obstructive pulmonary diseases (COPD), transplant rejection, tumor, and lymphedema, 3) familiarize with approved therapies based on the discoveries from vascular biology, 4) ask important questions for research.