课程名称 Course Title
Vascular biology in health and disease
For hypoxia-related research, I have been collaborating the 2019 Nobel Laureate, Dr. Gregg Semenza (Johns Hopkins University) for more than 10 years. My most recent NIH R01 grant supports research ofhypoxia in lymphatic biology. The goal of this course is to help students: 1) understand basics ofvascular biology (both the blood and lymphatic vascular systems) in health; I will cover vascular development and homeostasis, 2) use basic concept of vascular biology to explain disease pathogenesis; I will cover pulmonary hypertension, chronic obstructive pulmonary diseases (COPD), transplant rejection, tumor, and lymphedema, 3) familiarize with approved therapies based on the discoveries from vascular biology, 4) ask important questions for research. To summarize, cardiovascular diseases are the leading cause ofdeath. There is a renewed understanding ofvascular pathobiology in various diseases. Knowledge ofbasic vascular science, coupled with critical thinking skill will help cultivate vascular biologists ofthe next generation and improve the health care ofpatients suffered from vascular diseases. More broadly, knowledge gleaned from this course will also equipment students with a better understanding ofcancer pathogenesis, because tumor vessels play important roles in tumor progression and affect treatment outcome. Finally, I hope my way ofteaching will stimulate students’ interest and passion for research.
课程大纲 Course Outline
I have a joint laboratory with Dr. Mark Nicolls (Chief of Stanford pulmonary and criticalcare division) at VA Palo Alto / Stanford University. We are interested in translational research on several diseases involving hypoxia and vascular inflammation, particularly lung diseases and lymphatic disorders. For hypoxia-related research, I have been collaborating the 2019 Nobel Laureate, Dr. Gregg Semenza (Johns Hopkins University) for more than 10 years. My most recent NIH R01 grant supports research of hypoxia in lymphatic biology. The goal of this course is to help students: 1) understand basics of vascular biology (both the blood and lymphatic vascular systems) in health; I will cover vascular development and homeostasis, 2) use basic concept of vascular biology to explain disease pathogenesis; I will cover pulmonary hypertension, chronic obstructive pulmonary diseases (COPD), transplant rejection, tumor, and lymphedema, 3) familiarize with approved therapies based on the discoveries from vascular biology, 4) ask important questions for research. To summarize, cardiovascular diseases are the leading cause of death. There is a renewed understanding of vascular pathobiology in various diseases. Knowledge of basic vascular science, coupled with critical thinking skill will help cultivate vascular biologists of the next generation and improve the health care of patients suffered from vascular diseases. More broadly, knowledge gleaned from this course will also equipment students with a better understanding of cancer pathogenesis, because tumor vessels play important roles in tumor progression and affect treatment outcome. Review articles and relevant papers from the leaders of the field will be employed as as teaching materia. Finally, I hope my way of teaching will stimulate students’ interest and passion for research.
